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Article

Concomitant deregulation of HIF1alpha and cell cycle proteins in VHL-mutated renal cell carcinomas.

Virchows Archiv : an international journal of pathology - 1 Sept 2005

Atkins Derek John, Gingert Christian, Justenhoven Christina, Schmahl Gerd Emil, Bonato Marcellus Stephanus, Brauch Hiltrud, Störkel Stephan

Abstract excerpt

Renal cell carcinomas (RCCs) of the clear cell type are associated with alteration of the von Hippel-Lindau (VHL) tumour suppressor gene as well as subsequent stabilization and over-expression of hypoxia inducible factor (HIF), which causes up-regulation of cyclin D1. On the basis of their ability to interact with cyclin D1 we investigated a number of cell cycle proteins to shed further light on the downstream...

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Source

Identifiers

PMID: 15991006
DOI: 10.1007/s00428-005-1262-y

Genes

VHL
CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Concomitant deregulation of HIF1alpha and cell cycle proteins in VHL-mutated renal cell carcinomas.PMID 15991006Read ↗

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