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Novel P1 chain-extended HIV protease inhibitors possessing potent anti-HIV activity and remarkable inverse antiviral resistance profiles.

Bioorganic & medicinal chemistry letters - 1 Aug 2005

Miller John F, Brieger Michael, Furfine Eric S, Hazen Richard J, Kaldor Istvan, Reynolds David, Sherrill Ronald G, Spaltenstein Andrew

Abstract excerpt

A novel series of tyrosine-derived HIV protease inhibitors was synthesized and evaluated for in vitro antiviral activity against wild-type virus and two protease inhibitor-resistant viruses. All of the compounds had wild-type antiviral activities that were similar to or greater than several currently marketed HIV protease inhibitors. In addition, a number of compounds in this series were more potent against the...

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Identifiers

PMID: 15990305
DOI: 10.1016/j.bmcl.2005.05.129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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