Article
Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus.
Bioorganic & medicinal chemistry letters - 19 May 2003
Lu Zhijian, Raghavan Subharekha, Bohn Joann, Charest Mark, Stahlhut Mark W, Rutkowski Carrie A, Simcoe Amy L, Olsen David B, Schleif William A, Carella Anthony, Gabryelski Lori, Jin Lixia, Lin Jiunn H, Emini Emilio, Chapman Kevin, Tata James R
Abstract excerpt
A series of highly potent HIV protease inhibitors have been designed and synthesized. These compounds are active against various clinical viral isolates as well as wild-type virus. The synthesis and biological activity of these HIV protease inhibitors are discussed.
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