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Article

Recent advances in the discovery and development of novel HIV-1 NNRTI platforms: 2006-2008 update.

Current medicinal chemistry - 1 Jan 2009

Zhan Peng, Liu Xinyong, Li Zhenyu

Abstract excerpt

Currently, the long-term usage of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in HIVAIDS patients eventually leads to the development of drug resistance and severe side effect. Therefore, it is imperative to look for the novel NNRTIs with potent and broad spectrum anti-mutant activity that are also safe and have excellent pharmacokinetic profiles. In this article, newly emerging NNRTIs scaffolds in...

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Anti-HIV Agents
Drug Resistance, Viral
HIV-1
HIV/AIDS drug development and treatment
HIV Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Molecular

Reverse Transcriptase Inhibitors

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PMID: 19689270
DOI: 10.2174/092986709788803231

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