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Article

P1-substituted symmetry-based human immunodeficiency virus protease inhibitors with potent antiviral activity against drug-resistant viruses.

Journal of medicinal chemistry - 27 Oct 2011

Degoey David A, Grampovnik David J, Chen Hui-Ju, Flosi William J, Klein Larry L, Dekhtyar Tatyana, Stoll Vincent, Mamo Mulugeta, Molla Akhteruzzaman, Kempf Dale J

Abstract excerpt

Because there is currently no cure for HIV infection, patients must remain on long-term drug therapy, leading to concerns over potential drug side effects and the emergence of drug resistance. For this reason, new and safe antiretroviral agents with improved potency against drug-resistant strains...

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Source

Identifiers

PMID: 21899332
DOI: 10.1021/jm201109t

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21899332-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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