Article
Overcoming HIV drug resistance through rational drug design based on molecular, biochemical, and structural profiles of HIV resistance.
Cellular and molecular life sciences : CMLS - 1 Aug 2006
Yin P D, Das D, Mitsuya H
Abstract excerpt
There are 20 available drugs for the treatment of human immunodeficiency virus (HIV) infection. With a single exception, all of these drugs inhibit either HIV reverse transcriptase or protease. Reverse transcriptase inhibitors can be further categorized as nucleoside/nucleotide analogs or non-nucleoside reverse transcriptase inhibitors. Resistance that has emerged against all available antiretroviral drugs...
Topics
- Anti-HIV Agents
- Drug Design
- Drug Resistance, Viral
- HIV
- HIV Infections
- HIV Protease Inhibitors
- HIV Reverse Transcriptase
- Humans
- Models, Molecular
- Mutation
- Nucleosides
- Peptides
- Reverse Transcriptase Inhibitors