Segregation analysis detects a major gene controlling blood infection levels in human malaria.

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Article

Segregation analysis detects a major gene controlling blood infection levels in human malaria.

American journal of human genetics - 1 Jun 1992

Abel L, Cot M, Mulder L, Carnevale P, Feingold J

Abstract excerpt

The profound influence that the genetic makeup of the host has on resistance to malaria infection has been established in numerous animal studies. This genetic heterogeneity is one of the main causes of the difficulties in developing an effective malaria vaccine. Segregation analysis is the first step in identifying the nature of genetic factors involved in the expression of human complex diseases, as infectious...

Topics

Adolescent
Adult
Age Factors
Alleles
Analysis of Variance
Animals
Child
Child, Preschool
Female
Genes, Recessive
Genetic Predisposition to Disease
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Infant

Malaria

Malaria, Falciparum

Male

Middle Aged

Pedigree

Source

Open in PubMed Open full text

Identifiers

PMID: 1598911
PMCID: PMC1682575

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1598911-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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