Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of a dominant negative CELF protein in vivo leads to altered muscle organization, fiber size, and subtype.

PloS one - 26 Apr 2011

Berger Dara S, Moyer Michelle, Kliment Gregory M, van Lunteren Erik, Ladd Andrea N

Abstract excerpt

BACKGROUND: CUG-BP and ETR-3-like factor (CELF) proteins regulate tissue- and developmental stage-specific alternative splicing in striated muscle. We previously demonstrated that heart muscle-specific expression of a nuclear dominant negative CELF protein in transgenic mice (MHC-CELFΔ) effectively disrupts endogenous CELF activity in the heart in vivo, resulting in impaired cardiac function. In this study,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Biomechanical Phenomena

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Nucleus

Share to Genes, Dominant

Share to Muscle Fibers, Skeletal

Share to Muscle Strength

Share to Myogenin

Share to Organ Size

Source

Open in PubMed Open full text

Identifiers

PMID: 21541285
DOI: 10.1371/journal.pone.0019274
PMCID: PMC3082560

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of a dominant negative CELF protein in vivo leads to altered muscle organization, fiber size, and subtype.PMID 21541285Read ↗

Increased nuclear but not cytoplasmic activities of CELF1 protein leads to muscle wastingSemantic proximity Read ↗

Cardiac tissue-specific repression of CELF activity disrupts alternative splicing and causes cardiomyopathy.Semantic proximity Read ↗

The CELF Family of RNA Binding Proteins Is Implicated in Cell-Specific and Developmentally Regulated Alternative SplicingSemantic proximity Read ↗

Repression of nuclear CELF activity can rescue CELF-regulated alternative splicing defects in skeletal muscle models of myotonic dystrophySemantic proximity Read ↗

The role of CELF proteins in neurological disordersSemantic proximity Read ↗

Transcriptional regulation and alternative splicing cooperate in muscle fiber-type specification in flies and mammalsSemantic proximity Read ↗

Bruno-3 regulates sarcomere component expression and contributes to muscle phenotypes of myotonic dystrophy type 1.Semantic proximity Read ↗

The importance of CELF control: molecular and biological roles of the CUG-BP, Elav-like family of RNA-binding proteins.Semantic proximity Read ↗

Contributions of alternative splicing to muscle type development and functionSemantic proximity Read ↗

Diversity and conservation of CELF1 and CELF2 RNA and protein expression patterns during embryonic development.Semantic proximity Read ↗

Coregulation of fast contractile protein transgene and glycolytic enzyme expression in mouse skeletal muscle.Semantic proximity Read ↗

Bruno 1/CELF regulates splicing and cytoskeleton dynamics to ensure correct sarcomere assembly in Drosophila flight musclesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.