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Article

An aromatic amino acid auxotrophic mutant of Bordetella bronchiseptica is attenuated and immunogenic in a mouse model of infection.

FEMS microbiology letters - 11 Apr 2003

McArthur Jason D, West Nicholas P, Cole Jason N, Jungnitz Heidrun, Guzmán Carlos A, Chin James, Lehrbach Philip R, Djordjevic Steven P, Walker Mark J

Abstract excerpt

We have constructed an aromatic amino acid auxotrophic mutant of Bordetella bronchiseptica, harbouring mutations in aroA and trpE to investigate the use of such a strain as a live-attenuated vaccine. B. bronchiseptica aroA trpE was unable to grow in minimal medium without aromatic supplementation. Compared to the parental wild-type strain, the mutant displayed significantly reduced abilities to invade and survive...

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Identifiers

PMID: 12694904
DOI: 10.1016/S0378-1097(03)00162-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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