Article
Notch and vascular smooth muscle cell phenotype.
Circulation research - 5 Dec 2008
Morrow David, Guha Shaunta, Sweeney Catherine, Birney Yvonne, Walshe Tony, O'Brien Colm, Walls Dermot, Redmond Eileen M, Cahill Paul A
Abstract excerpt
The Notch signaling pathway is critical for cell fate determination during embryonic development, including many aspects of vascular development. An emerging paradigm suggests that the Notch gene regulatory network is often recapitulated in the context of phenotypic modulation of vascular smooth muscle cells (VSMC), vascular remodeling, and repair in adult vascular disease following injury. Notch ligand receptor...
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