Article
Variation in the interleukin-6 gene is associated with impaired cognitive development in children born prematurely: a preliminary study.
Pediatric research - 1 Jul 2005
Harding David, Brull David, Humphries Steve E, Whitelaw Andrew, Montgomery Hugh, Marlow Neil
Abstract excerpt
The pro-inflammatory cytokine IL-6 may be neurocytopathogenic, and elevated levels are associated with impaired neurological outcome among children born prematurely. However, the precise mechanisms underlying this association remain unclear. The rare C (rather than G) variant at position -572 in the IL-6 gene is associated with an increased IL-6 synthetic response. If IL-6 mediates cerebral injury, we would...
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