Article
Cognitive outcome and cyclo-oxygenase-2 gene (-765 G/C) variation in the preterm infant.
Archives of disease in childhood. Fetal and neonatal edition - 1 Mar 2007
Harding D R, Humphries S E, Whitelaw A, Marlow N, Montgomery H E
Abstract excerpt
BACKGROUND: Cyclo-oxygenase (COX) inhibition by indomethacin does not result in an improvement in long-term neurocognitive outcome, despite reducing the incidence of both severe intraventricular haemorrhage and white matter injury visible on ultrasound. Diffuse brain injury after preterm birth may have inflammatory origins. These two points suggest that, in the preterm brain, COX inhibition may have a dominant...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
