Article
Genetic susceptibility to viral exposure may increase the risk of cerebral palsy.
The Australian & New Zealand journal of obstetrics & gynaecology - 1 Jun 2009
Djukic Michael, Gibson Catherine S, Maclennan Alastair H, Goldwater Paul N, Haan Eric A, McMichael Gai, Priest Kevin, Dekker Gustaaf A, Hague William M, Chan Annabelle, Rudzki Zbigniew, VAN Essen Phillipa, Khong T Yee, Morton Mark R, Ranieri Enzo, Scott Heather, Tapp Heather, Casey Graeme
Abstract excerpt
AIM: Cytokine polymorphisms may alter the fetal inflammatory response, increasing susceptibility to cerebral palsy (CP). This study investigates associations between selected inflammatory mediator and cytokine gene polymorphisms (Toll-like receptor-4 (TLR-4) Asp299Gly, interleukin-6 G-174C and interleukin-4 C-589T) and CP from 443 CP infants and 883 control infants. Results were correlated with viral nucleic...
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