Article
Quantitative Evaluation of the Transcriptional Activity of Steroid Hormone Receptor Mutants and Variants Using a Single Vector With Two Reporters and a Receptor Expression Cassette.
Frontiers in endocrinology - 1 Jan 2020
Ji Huimin, Li Ying, Liu Zhao, Tang Min, Zou Lihui, Su Fei, Zhang Yaqun, Zhang Junhua, Li Hexin, Li Lin, Ai Bin, Ma Jie, Wang Lunan, Liu Ming, Xiao Fei
Abstract excerpt
Although the rapid development of high-throughput sequencing has led to the identification of a large number of truncated or mutated steroid hormone receptor (SHR) variants, their clinical relevance remains to be defined. A platform for functional analysis of these SHR variants in cells would be instrumental for better assessing their impact on normal physiology and SHR-associated diseases. Here we have developed...
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