Article
Allelic dosage analysis with genotyping microarrays.
Biochemical and biophysical research communications - 12 Aug 2005
Ishikawa Shumpei, Komura Daisuke, Tsuji Shingo, Nishimura Kunihiro, Yamamoto Shogo, Panda Binaya, Huang Jing, Fukayama Masashi, Jones Keith W, Aburatani Hiroyuki
Abstract excerpt
Genomic alternations, including dosage and allelic imbalance, constitute a major basis of neoplastic and other genetic disorders. Using oligonucleotide genotyping microarrays, here we report the development and usage of an algorithm, called genome imbalance map (GIM) algorithm, for allelic as well as total gene dosage analysis. Using the GIM algorithm, global genome imbalance status at over 100,000 loci was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
