Article
Risk assessment of p53 genotypes and haplotypes in tobacco-associated leukoplakia and oral cancer patients from eastern Idia.
International journal of cancer - 10 Dec 2005
Mitra Sayan, Sikdar Nilabja, Misra Chaitali, Gupta Shalini, Paul Ranjan Rashmi, Roy Bidyut, Panda Chinmay Kumar, Roychoudhury Susanta
Abstract excerpt
The role of 3 p53 polymorphisms (16 bp duplication at intron 3, codon 72 Arg/Pro and intron 6 NciI RFLP at np 13494) as potential markers for indicating cancer risk remains inconclusive. In our case-control study consisting of 197 leukoplakia and 310 oral squamous cell carcinoma (SCC) patients and 348 controls, genotype frequencies at these 3 p53 loci were determined by PCR-RFLP method and analyzed by multiple...
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