Article
Abundant neuritic inclusions and microvacuolar changes in a case of diffuse Lewy body disease with the A53T mutation in the alpha-synuclein gene.
Acta neuropathologica - 1 Sept 2005
Yamaguchi Keiji, Cochran Elizabeth J, Murrell Jill R, Polymeropoulos Mihael H, Shannon Kathleen M, Crowther R Anthony, Goedert Michel, Ghetti Bernardino
Abstract excerpt
We report here a case of diffuse Lewy body disease with the A53T mutation in the alpha-synuclein gene. The proband presented at the age of 41 years with parkinsonism that was poorly responsive to levodopa. She subsequently developed cognitive impairment and moderate dementia, and died at the age of 50. Her father, paternal grandfather and uncle were all reported to have suffered from Parkinson's disease. Staining...
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