Expression and purification of chaperone-active recombinant clusterin.

Abstract excerpt

Clusterin was the first described secreted mammalian chaperone and is implicated as being a key player in both intra- and extracellular proteostasis. Its unique combination of structural features and biological chaperone activity has, however, previously made it very challenging to express and purify the protein in a correctly processed and chaperone-active form. While there are multiple reports in the literature...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chromatography, Gel
• Share to Clusterin
• Share to Glutathione Transferase