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Article

The role of the carboxyl terminus in ClC chloride channel function.

The Journal of biological chemistry - 26 Mar 2004

Hebeisen Simon, Biela Alexander, Giese Bernd, Müller-Newen Gerhard, Hidalgo Patricia, Fahlke Christoph

Abstract excerpt

The human muscle chloride channel ClC-1 has a 398-amino acid carboxyl-terminal domain that resides in the cytoplasm and contains two CBS (cystathionine-beta-synthase) domains. To examine the role of this region, we studied various carboxyl-terminal truncations by heterologous expression in mammal...

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Source

Identifiers

PMID: 14718533
DOI: 10.1074/jbc.M312649200

Genes

CBS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14718533-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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The role of the carboxyl terminus in ClC chloride channel function.PMID 14718533Read ↗

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The analysis of myotonia congenita mutations discloses functional clusters of amino acids within the CBS2 domain and the C-terminal peptide of the ClC-1 channel.Semantic proximity Read ↗

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A role for CBS domain 2 in trafficking of chloride channel CLC-5.Semantic proximity Read ↗

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From tonus to tonicity: physiology of CLC chloride channels.Semantic proximity Read ↗

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