Article

Dark selection for JAK/STAT-inhibitor resistance in chronic myelomonocytic leukemia

2017-10-30

Abstract excerpt

Acquired therapy resistance to cancer treatment is a common and serious clinical problem. The classic U-shape model for the emergence of resistance supposes that: (1) treatment changes the selective pressure on the treatment-naive tumour; (2) this shifting pressure creates a proliferative or survival difference between sensitive cancer cells and either an existing or de novo mutant; (3) the resistant cells then o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f6d8272b-1b74-5c2c-ad53-2e79d841ee89
DOI: 10.1101/211151

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dark selection for JAK/STAT-inhibitor resistance in chronic myelomonocytic leukemiaDOI 10.1101/211151Read

Drug resistance in cancer: Principles of emergence and preventionSemantic proximity Read

Interplay of mutations, alternate mechanisms, and treatment breaks in leukaemia: Understanding and implications studied with stochastic models.Semantic proximity Read

Multi-scale Predictions of Drug Resistance Epidemiology Identify Design Principles for Rational Drug Design.Semantic proximity Read

Understanding the role of phenotypic switching in cancer drug resistance.Semantic proximity Read

Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressuresSemantic proximity Read

Stochastic modelling of tyrosine kinase inhibitor rotation therapy in chronic myeloid leukaemiaSemantic proximity Read

Differential response to cytotoxic therapy explains treatment dynamics of acute myeloid leukaemia patients: insights from a mathematical modelling approachSemantic proximity Read

Fitness conferred by BCR-ABL kinase domain mutations determines the risk of pre-existing resistance in chronic myeloid leukemia.Semantic proximity Read

Drug resistance in cancer mechanisms and modelsSemantic proximity Read

The ecology in the hematopoietic stem cell niche determines the clinical outcome in chronic myeloid leukemiaSemantic proximity Read

Mutation and cell state compatibility is required and targetable in Ph <i>+</i> acute lymphoblastic leukemia minimal residual diseaseSemantic proximity Read

Evolutionary rescue is promoted in compact cellular populationsSemantic proximity Read