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Functional antagonism between <i>Helicobacter pylori</i> CagA and vacuolating toxin VacA in control of the NFAT signaling pathway in gastric epithelial cells

24 Jun 2005

Abstract excerpt

Chronic infection with cagA-positive Helicobacter pylori is associated with the development of atrophic gastritis, peptic ulcers, and gastric adenocarcinoma. The cagA gene product CagA is injected into gastric epithelial cells, where it undergoes tyrosine phosphorylation by Src family kinases. Translocated CagA disturbs cellular functions by physically interacting with and deregulating intracellular signaling...

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PMID: 15980153
DOI: 10.1073/pnas.0502529102

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