Article
Cyp2a6 is a principal enzyme involved in hydroxylation of 1,7-dimethylxanthine, a main caffeine metabolite, in humans.
Drug metabolism and disposition: the biological fate of chemicals - 1 Sept 2005
Kimura Miyuki, Yamazaki Hiroshi, Fujieda Masaki, Kiyotani Kazuma, Honda Goro, Saruwatari Junji, Nakagawa Kazuko, Ishizaki Takashi, Kamataki Tetsuya
Abstract excerpt
In a caffeine test previously performed with healthy Japanese volunteers, we found that the CYP1A2 index defined as urinary {5-acetylamino-6-amine-3-methyluracil (AAMU)+1-methylxanthine (1X)+1-methyluric acid (1 U)}/1,7-dimethyluric acid (17 U) was affected by the whole deleted allele of CYP2A6 (CYP2A6*4). Since the high value of the CYP1A2 index could be caused by a low urinary concentration of 17 U, we...
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