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A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells

10 Feb 2020

Abstract excerpt

BACKGROUND: Quiescence (G0) is a transient, cell cycle-arrested state. By entering G0, cancer cells survive unfavorable conditions such as chemotherapy and cause relapse. While G0 cells have been studied at the transcriptome level, how post-transcriptional regulation contributes to their chemoresistance remains unknown. RESULTS: We induce chemoresistant and G0 leukemic cells by serum starvation or chemotherapy...

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PMID: 32039742
DOI: 10.1186/s13059-020-1936-4

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