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Article

Homocysteine remethylation enzyme polymorphisms and increased risks for neural tube defects.

Molecular genetics and metabolism - 1 Mar 2003

Zhu Huiping, Wicker Ned J, Shaw Gary M, Lammer Edward J, Hendricks Kate, Suarez Lucina, Canfield Mark, Finnell Richard H

Abstract excerpt

Folic acid supplementation can effectively reduce the risk of neural tube defects (NTDs); however, the mechanism underlying this beneficial effect remains unclear. Recent evidence suggests that certain folate pathway genes, as well as those related to homocysteine metabolism might be contributing to this effect. The purpose of this study is to investigate whether gene polymorphisms of methionine synthase (MTR)...

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Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Share to Ferredoxin-NADP Reductase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Infant, Newborn

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Share to Polymorphism, Genetic

Share to Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 12649067
DOI: 10.1016/s1096-7192(03)00008-8

Genes

MTRR
MTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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