Article
Transcobalamin II receptor polymorphisms are associated with increased risk for neural tube defects.
Journal of medical genetics - 1 Oct 2010
Pangilinan F, Mitchell A, VanderMeer J, Molloy A M, Troendle J, Conley M, Kirke P N, Sutton M, Sequeira J M, Quadros E V, Scott J M, Mills J L, Brody L C
Abstract excerpt
OBJECTIVE: Women who have low cobalamin (vitamin B(12)) levels are at increased risk for having children with neural tube defects (NTDs). The transcobalamin II receptor (TCblR) mediates uptake of cobalamin into cells. Inherited variants in the TCblR gene as NTD risk factors were evaluated. METHODS: Case-control and family-based tests of association were used to screen common variation in TCblR as genetic risk...
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