HLA-A alleles and infectious mononucleosis suggest a critical role for cytotoxic T-cell response in EBV-related Hodgkin lymphoma.

doi:10.1073/pnas.0915054107

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Article

HLA-A alleles and infectious mononucleosis suggest a critical role for cytotoxic T-cell response in EBV-related Hodgkin lymphoma.

Proceedings of the National Academy of Sciences of the United States of America - 6 Apr 2010

Hjalgrim Henrik, Rostgaard Klaus, Johnson Paul C D, Lake Annette, Shield Lesley, Little Ann-Margaret, Ekstrom-Smedby Karin, Adami Hans-Olov, Glimelius Bengt, Hamilton-Dutoit Stephen, Kane Eleanor, Taylor G Malcolm, McConnachie Alex, Ryder Lars P, Sundstrom Christer, Andersen Paal Skytt, Chang Ellen T, Alexander Freda E, Melbye Mads, Jarrett Ruth F

Abstract excerpt

A proportion of classical Hodgkin lymphoma (HL) is believed to be causally related to infection with the ubiquitous lymphotropic EBV. The determining factors for development of EBV-related HL remain poorly understood, but likely involve immunological control of the viral infection. Accordingly, markers of the HLA class I region have been associated with risk of EBV-related HL. To study the host genetic component...

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Identifiers

PMID: 20308568
DOI: 10.1073/pnas.0915054107
PMCID: PMC2851961

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