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Article

Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity.

The Journal of biological chemistry - 26 Aug 2005

Ameziane-El-Hassani Rabii, Morand Stanislas, Boucher Jean-Luc, Frapart Yves-Michel, Apostolou Daphné, Agnandji Diane, Gnidehou Sédami, Ohayon Renée, Noël-Hudson Marie-Sophie, Francon Jacques, Lalaoui Khalid, Virion Alain, Dupuy Corinne

Abstract excerpt

Duox2 (and probably Duox1) is a glycoflavoprotein involved in thyroid hormone biosynthesis, as the thyroid H2O2 generator functionally associated with Tpo (thyroperoxidase). So far, because of the impairment of maturation and of the targeting process, transfecting DUOX into nonthyroid cell lines has not led to the expression of a functional H2O2-generating system at the plasma membrane. For the first time, we...

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Source

Identifiers

PMID: 15972824
DOI: 10.1074/jbc.M500516200

Genes

DUOX1
DUOX2
TPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity.PMID 15972824Read ↗

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Identification of a Novel Partner of DuoxSemantic proximity Read ↗

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