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Article

Targeting of the dual oxidase 2 N-terminal region to the plasma membrane.

The Journal of biological chemistry - 16 Jul 2004

Morand Stanislas, Agnandji Diane, Noel-Hudson Marie-Sophie, Nicolas Valérie, Buisson Sandrine, Macon-Lemaitre Laetitia, Gnidehou Sédami, Kaniewski Jacques, Ohayon Renée, Virion Alain, Dupuy Corinne

Abstract excerpt

Dual oxidase 2 (Duox2) is a cell surface glycoprotein that probably provides thyroperoxidase with the H2O2 required to catalyze thyroid hormone synthesis. No functional H2O2-generating system has yet been obtained after transfecting Duox2 into non-thyroid cell lines, because it is retained in the endoplasmic reticulum (ER). We investigated the level of maturation of various Duox2 truncated proteins in an attempt...

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Identifiers

PMID: 15150274
DOI: 10.1074/jbc.M405406200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Targeting of the dual oxidase 2 N-terminal region to the plasma membrane.PMID 15150274Read ↗

Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity.Semantic proximity Read ↗

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Mice deficient in dual oxidase maturation factors are severely hypothyroid.Semantic proximity Read ↗

Conformation of the N-Terminal Ectodomain Elicits Different Effects on DUOX Function: A Potential Impact on Congenital Hypothyroidism Caused by a H2O2 Production Defect.Semantic proximity Read ↗

New phenotypes in thyroid dyshormonogenesis: hypothyroidism due to DUOX2 mutations.Semantic proximity Read ↗

Biallelic inactivation of the dual oxidase maturation factor 2 (DUOXA2) gene as a novel cause of congenital hypothyroidism.Semantic proximity Read ↗

The role of DUOXA2 in the clinical diagnosis of paediatric congenital hypothyroidism.Semantic proximity Read ↗

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