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Article

Mice deficient in dual oxidase maturation factors are severely hypothyroid.

Molecular endocrinology (Baltimore, Md.) - 1 Mar 2012

Grasberger Helmut, De Deken Xavier, Mayo Olga Barca, Raad Houssam, Weiss Mia, Liao Xiao-Hui, Refetoff Samuel

Abstract excerpt

Dual oxidases (DUOX1 and DUOX2) are evolutionary conserved reduced nicotinamide adenine dinucleotide phosphate oxidases responsible for regulated hydrogen peroxide (H(2)O(2)) release of epithelial cells. Specific maturation factors (DUOXA1 and DUOXA2) are required for targeting of functional DUOX enzymes to the cell surface. Mutations in the single-copy Duox and Duoxa genes of invertebrates cause developmental...

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Source

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Identifiers

PMID: 22301785
DOI: 10.1210/me.2011-1320
PMCID: PMC3286189

Genes

DUOX2
DUOX1
DUOXA1
DUOXA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mice deficient in dual oxidase maturation factors are severely hypothyroid.PMID 22301785Read ↗

Defects of thyroidal hydrogen peroxide generation in congenital hypothyroidism.Semantic proximity Read ↗

New phenotypes in thyroid dyshormonogenesis: hypothyroidism due to DUOX2 mutations.Semantic proximity Read ↗

Biallelic inactivation of the dual oxidase maturation factor 2 (DUOXA2) gene as a novel cause of congenital hypothyroidism.Semantic proximity Read ↗

A single copy of the recently identified dual oxidase maturation factor (DUOXA) 1 gene produces only mild transient hypothyroidism in a patient with a novel biallelic DUOXA2 mutation and monoallelic DUOXA1 deletion.Semantic proximity Read ↗

Roles of DUOX-Mediated Hydrogen Peroxide in Metabolism, Host Defense, and SignalingSemantic proximity Read ↗

Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent.Semantic proximity Read ↗

The role of DUOXA2 in the clinical diagnosis of paediatric congenital hypothyroidism.Semantic proximity Read ↗

Conformation of the N-Terminal Ectodomain Elicits Different Effects on DUOX Function: A Potential Impact on Congenital Hypothyroidism Caused by a H2O2 Production Defect.Semantic proximity Read ↗

Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cellsSemantic proximity Read ↗

Congenital hypothyroidism, dwarfism, and hearing impairment caused by a missense mutation in the mouse dual oxidase 2 gene, Duox2.Semantic proximity Read ↗

Activation of dual oxidases Duox1 and Duox2: differential regulation mediated by camp-dependent protein kinase and protein kinase C-dependent phosphorylation.Semantic proximity Read ↗

Inhibition of the thyroid hormonogenic H2O2 production by Duox/DuoxA in zebrafish reveals VAS2870 as a new goitrogenic compound.Semantic proximity Read ↗

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