Article
Activation of dual oxidases Duox1 and Duox2: differential regulation mediated by camp-dependent protein kinase and protein kinase C-dependent phosphorylation.
The Journal of biological chemistry - 13 Mar 2009
Rigutto Sabrina, Hoste Candice, Grasberger Helmut, Milenkovic Milutin, Communi David, Dumont Jacques E, Corvilain Bernard, Miot Françoise, De Deken Xavier
Abstract excerpt
Dual oxidases were initially identified as NADPH oxidases producing H(2)O(2) necessary for thyroid hormone biosynthesis. The crucial role of Duox2 has been demonstrated in patients suffering from partial iodide organification defect caused by bi-allelic mutations in the DUOX2 gene. However, the Duox1 function in thyroid remains elusive. We optimized a functional assay by co-expressing Duox1 or Duox2 with their...
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