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Article

Identification of a Novel Partner of Duox

24 Nov 2004

Abstract excerpt

H(2)O(2) is a crucial substrate of thyroproxidase (TPO) to iodinate thyroglobulin and synthesize thyroid hormones in thyroid. ThOX proteins (thyroid oxidase) also called Duox are believed to be responsible for H(2)O(2) generation. Duoxs expressed in transfected cells do not generate an active system, nor permit their membrane localization suggesting that other proteins are required to fulfill these functions. In...

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Share to Heme Oxygenase-1 and Carbon Monoxide
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PMID: 15561711
DOI: 10.1074/jbc.m407709200

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a Novel Partner of DuoxPMID 15561711Read ↗

Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity.Semantic proximity Read ↗

Activation of dual oxidases Duox1 and Duox2: differential regulation mediated by camp-dependent protein kinase and protein kinase C-dependent phosphorylation.Semantic proximity Read ↗

New phenotypes in thyroid dyshormonogenesis: hypothyroidism due to DUOX2 mutations.Semantic proximity Read ↗

Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent.Semantic proximity Read ↗

Conformation of the N-Terminal Ectodomain Elicits Different Effects on DUOX Function: A Potential Impact on Congenital Hypothyroidism Caused by a H2O2 Production Defect.Semantic proximity Read ↗

Identification and functional studies of two new dual-oxidase 2 (DUOX2) mutations in a child with congenital hypothyroidism and a eutopic normal-size thyroid gland.Semantic proximity Read ↗

Roles of DUOX-Mediated Hydrogen Peroxide in Metabolism, Host Defense, and SignalingSemantic proximity Read ↗

The Human, but Not Rat, dio2 Gene Is Stimulated by Thyroid Transcription Factor-1 (TTF-1)Semantic proximity Read ↗

Structural and functional characterization of the two human ThOX/Duox genes and their 5′-flanking regionsSemantic proximity Read ↗

Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cellsSemantic proximity Read ↗

A single copy of the recently identified dual oxidase maturation factor (DUOXA) 1 gene produces only mild transient hypothyroidism in a patient with a novel biallelic DUOXA2 mutation and monoallelic DUOXA1 deletion.Semantic proximity Read ↗

Conserved cysteine residues provide a protein-protein interaction surface in dual oxidase (DUOX) proteins.Semantic proximity Read ↗

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