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Article

Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent.

The Journal of biological chemistry - 7 Jul 2006

Grasberger Helmut, Refetoff Samuel

Abstract excerpt

Dual oxidase 2 (DUOX2), an NADPH:O(2) oxidoreductase flavoprotein, is a component of the thyroid H(2)O(2) generator crucial for hormone synthesis at the apical membrane. Mutations in DUOX2 produce congenital hypothyroidism in humans. However, no functional DUOX-based NADPH oxidase has ever been reconstituted at the plasma membrane of transfected cells. It has been proposed that DUOX retention in the endoplasmatic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Flavoproteins

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Share to Sequence Analysis, Protein

Source

Identifiers

PMID: 16651268
DOI: 10.1074/jbc.C600095200

Genes

DUOX2
DUOXA2
DUOX1
DUOXA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent.PMID 16651268Read ↗

The role of DUOXA2 in the clinical diagnosis of paediatric congenital hypothyroidism.Semantic proximity Read ↗

Mice deficient in dual oxidase maturation factors are severely hypothyroid.Semantic proximity Read ↗

Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cellsSemantic proximity Read ↗

Biallelic inactivation of the dual oxidase maturation factor 2 (DUOXA2) gene as a novel cause of congenital hypothyroidism.Semantic proximity Read ↗

A single copy of the recently identified dual oxidase maturation factor (DUOXA) 1 gene produces only mild transient hypothyroidism in a patient with a novel biallelic DUOXA2 mutation and monoallelic DUOXA1 deletion.Semantic proximity Read ↗

New phenotypes in thyroid dyshormonogenesis: hypothyroidism due to DUOX2 mutations.Semantic proximity Read ↗

Activation of dual oxidases Duox1 and Duox2: differential regulation mediated by camp-dependent protein kinase and protein kinase C-dependent phosphorylation.Semantic proximity Read ↗

Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity.Semantic proximity Read ↗

Targeting of the dual oxidase 2 N-terminal region to the plasma membrane.Semantic proximity Read ↗

Conformation of the N-Terminal Ectodomain Elicits Different Effects on DUOX Function: A Potential Impact on Congenital Hypothyroidism Caused by a H2O2 Production Defect.Semantic proximity Read ↗

Roles of DUOX-Mediated Hydrogen Peroxide in Metabolism, Host Defense, and SignalingSemantic proximity Read ↗

A novel dual oxidase maturation factor 2 gene mutation for congenital hypothyroidism.Semantic proximity Read ↗

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