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Article

Virulence attenuation and live vaccine potential of aroA, crp cdt cya, and plasmid-cured mutants of Salmonella enterica serovar Abortusovis in mice and sheep.

Infection and immunity - 1 Jul 2005

Uzzau Sergio, Marogna Gavino, Leori Guido Sisinnio, Curtiss Roy, Schianchi Giuseppe, Stocker Bruce A D, Rubino Salvatore

Abstract excerpt

Three live vaccine candidates of Salmonella enterica subspecies I serotype Abortusovis (aroA, cya crp cdt, and plasmid-cured strains) have been developed, and their efficacies in inducing humoral antibodies and protecting against abortion after challenge with wild-type strain SS44 were evaluated in sheep. Following estrus synchronization, animals were immunized 3 weeks after fertilization and boosted once 3 weeks...

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Identifiers

PMID: 15972523
DOI: 10.1128/IAI.73.7.4302-4308.2005
PMCID: PMC1168578

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Source receipt: pubmed, retrieved 7 Sept 2026.

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