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Search for live attenuated vaccine candidate against edwardsiellosis by mutating virulence-related genes of fish pathogen Edwardsiella tarda.

Letters in applied microbiology - 1 Oct 2011

Xiao J, Chen T, Wang Q, Liu Q, Wang X, Lv Y, Wu H, Zhang Y

Abstract excerpt

AIMS: The aims of this study were to construct and evaluate the live attenuated vaccine against edwardsiellosis on zebra fish model. METHODS AND RESULTS: In this study, the deletion mutant of aroC gene for the biosynthesis of chorismic acid in Edwardsiella tarda EIB202 was firstly constructed by allelic exchange strategy. According to the genome information, 19 double mutants and one multiple mutant were...

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PMID: 21777261
DOI: 10.1111/j.1472-765X.2011.03126.x

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