Article
Tumor suppressor gene alterations in malignant gliomas: histopathological associations and prognostic evaluation.
International journal of oncology - 1 Sept 1999
James C D, Galanis E, Frederick L, Kimmel D W, Cunningham J M, Atherton-Skaff P J, O'Fallon J R, Jenkins R B, Buckner J C, Hunter S B, Olson J J, Scheithauer B W
Abstract excerpt
We have examined a series of 135 gliomas for alterations of the p53, CDKN2A (p16) and PTEN tumor suppressor genes (TSGs) in order to evaluate the incidence of their inactivation as a function of tumor malignancy and cellular differentiation, and to examine potential associations with patient outcome. The composition of this series, classified using WHO criteria, is as follows: 27 grade 2 tumors (11 astrocytomas,...
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