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Article

Human thiopurine S-methyltransferase pharmacogenetics: variant allozyme misfolding and aggresome formation.

Proceedings of the National Academy of Sciences of the United States of America - 28 Jun 2005

Wang Liewei, Nguyen Tien V, McLaughlin Richard W, Sikkink Laura A, Ramirez-Alvarado Marina, Weinshilboum Richard M

Abstract excerpt

Thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs. TPMT genetic polymorphisms represent a striking example of the potential clinical value of pharmacogenetics. Subjects homozygous for TPMT*3A, the most common variant allele for low activity, an allele that encodes a protein with two changes in amino acid sequence, are at greatly increased risk for life-threatening toxicity when...

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Identifiers

PMID: 15967990
DOI: 10.1073/pnas.0502352102
PMCID: PMC1153717

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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