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Article

Thiopurine S-methyltransferase pharmacogenetics: chaperone protein association and allozyme degradation.

Pharmacogenetics - 1 Sept 2003

Wang Liewei, Sullivan William, Toft David, Weinshilboum Richard

Abstract excerpt

Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs such as 6-mercaptopurine. A common genetic polymorphism for TPMT is associated with large individual variations in thiopurine drug toxicity and therapeutic efficacy. TPMT*3A, the most common variant allele in Caucasians, has two alterations in amino acid sequence, resulting in striking decreases in TPMT protein levels. This...

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Source

Identifiers

PMID: 12972954
DOI: 10.1097/01.fpc.0000054124.14659.99

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Thiopurine S-methyltransferase pharmacogenetics: chaperone protein association and allozyme degradation.PMID 12972954Read ↗

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