Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells

17 Jun 2005

Abstract excerpt

To examine the impact of tumors on the immune system, we compared global gene expression profiles of peripheral blood T cells from previously untreated patients with B cell chronic lymphocytic leukemia (CLL) with those from age-matched healthy donors. Although the cells analyzed were not part of the malignant clone, analysis revealed differentially expressed genes, mainly involved in cell differentiation in CD4...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Lymphocytic Leukemia Research
Share to Immunodeficiency and Autoimmune Disorders
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15965501
DOI: 10.1172/jci24176

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cellsPMID 15965501Read ↗

T Cells in Chronic Lymphocytic Leukemia: A Two-Edged Sword.Semantic proximity Read ↗

T cells in chronic lymphocytic leukemia display dysregulated expression of immune checkpoints and activation markers.Semantic proximity Read ↗

T-cell dysfunction in chronic lymphocytic leukemia from an epigenetic perspectiveSemantic proximity Read ↗

Molecular Interactions Between Innate and Adaptive Immune Cells in Chronic Lymphocytic Leukemia and Their Therapeutic ImplicationsSemantic proximity Read ↗

Phenotypic alteration of CD8+ T cells in chronic lymphocytic leukemia is associated with epigenetic reprogramming.Semantic proximity Read ↗

Molecular pathogenesis of chronic lymphocytic leukemia: factors and signaling pathways regulating cell growth and survivalSemantic proximity Read ↗

Gene expression profiling of chronic lymphocytic leukemia can discriminate cases with stable disease and mutated Ig genes from those with progressive disease and unmutated Ig genesSemantic proximity Read ↗

New insights into the pathogenesis of chronic lymphocytic leukemiaSemantic proximity Read ↗

Differential regulation of gene expression following CD40 activation of leukemic compared to healthy B cells.Semantic proximity Read ↗

Dendritic cells from chronic lymphocytic leukemia patients are normal regardless of Ig V gene mutation status.Semantic proximity Read ↗

Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells.Semantic proximity Read ↗

Peripheral blood T cells in acute myeloid leukemia (AML) patients at diagnosis have abnormal phenotype and genotype and form defective immune synapses with AML blasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.