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Article

Angiographic features of transgenic mice with increased expression of human serine protease HTRA1 in retinal pigment epithelium.

Investigative ophthalmology & visual science - 22 May 2014

Kumar Sandeep, Berriochoa Zachary, Ambati Balamurali K, Fu Yingbin

Abstract excerpt

PURPOSE: Polypoidal choroidal vasculopathy (PCV) is characterized by a branching vascular network (BVN) of choroid that terminates in polypoidal dilations. We have previously reported the generation of the first PCV model by transgenically expressing human HTRA1 (hHTRA1(+)), a multifunctional ser...

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Source

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Identifiers

PMID: 24854852
DOI: 10.1167/iovs.13-13111
PMCID: PMC4581615

Genes

HTRA1
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24854852-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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