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Article

The Drosophila fragile X mental retardation protein controls actin dynamics by directly regulating profilin in the brain.

Current biology : CB - 21 Jun 2005

Reeve Simon P, Bassetto Laura, Genova Ginka K, Kleyner Yelena, Leyssen Maarten, Jackson F Rob, Hassan Bassem A

Abstract excerpt

Loss of Fragile X mental retardation protein (FMRP) function causes the highly prevalent Fragile X syndrome [1 and 2]. Identifying targets for the RNA binding FMRP is a major challenge and an important goal of research into the pathology of the disease. Perturbations in neuronal development and circadian behavior are seen in Drosophila dfmr1 mutants. Here we show that regulation of the actin cytoskeleton is under...

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Identifiers

PMID: 15964283
DOI: 10.1016/j.cub.2005.05.050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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