Article
Fragile X protein controls the efficacy of mRNA transport in Drosophila neurons.
Molecular and cellular neurosciences - 1 Oct 2008
Estes Patricia S, O'Shea Michele, Clasen Sara, Zarnescu Daniela C
Abstract excerpt
Fragile X syndrome, the most common form of inherited mental retardation is caused by mutations in the FMR1 gene. FMR1 encodes an RNA-binding protein thought to control the transport and translation of target mRNAs. While the function of FMRP in translational control has been clearly demonstrated, its role in mRNA transport and localization in neurons remains elusive. Using a genetically encoded mRNA imaging...
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