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Human immunodeficiency virus type 1 KK26-27 matrix mutants display impaired infectivity, circularization and integration but not nuclear import.

Virology - 15 Aug 2005

Mannioui Abdelkrim, Nelson Elisabeth, Schiffer Cecile, Felix Nathalie, Le Rouzic Erwann, Benichou Serge, Gluckman Jean Claude, Canque Bruno

Abstract excerpt

We analyzed the role of human immunodeficiency virus (HIV)-1 matrix protein (MA) during the virus replication afferent phase. Single-round infection of H9 T lymphocytes showed that the combined mutation of MA Lys residues 26-27 in MA reported nuclear localization signal (NLS)-1 impaired infectivity, abrogated 2-LTR-circle formation and significantly reduced integration. However, the mutation did not affect viral...

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PMID: 15963546
DOI: 10.1016/j.virol.2005.05.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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