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Article

Two nuclear localization signals in the HIV-1 matrix protein regulate nuclear import of the HIV-1 pre-integration complex.

Journal of molecular biology - 2 Jun 2000

Haffar O K, Popov S, Dubrovsky L, Agostini I, Tang H, Pushkarsky T, Nadler S G, Bukrinsky M

Abstract excerpt

Replication of HIV-1 in non-dividing and slowly proliferating cell populations depends on active import of the viral pre-integration complex (PIC) into the cell nucleus. While it is commonly accepted that this process is mediated by an interaction between the HIV-1 PIC and the cellular nuclear import machinery, controversial results have been reported concerning the mechanisms of this interaction. Here, we...

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Identifiers

PMID: 10860744
DOI: 10.1006/jmbi.2000.3768

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Source receipt: pubmed, retrieved 7 Sept 2026.

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