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Article

Perforin and Fas cytolytic pathways coordinately shape the selection and diversity of CD8+-T-cell escape variants of influenza virus.

Journal of virology - 1 Jul 2005

Price Graeme E, Huang Lei, Ou Rong, Zhang Menghua, Moskophidis Demetrius

Abstract excerpt

Antigenic variation is a viral strategy exploited to promote survival in the face of the host immune response and represents a major challenge for efficient vaccine development. Influenza viruses are pathogens with high transmissibility and mutation rates, enabling viral escape from immunity induced by prior infection or vaccination. Intense selection from neutralizing antibody drives antigenic changes in the...

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Identifiers

PMID: 15956596
DOI: 10.1128/JVI.79.13.8545-8559.2005
PMCID: PMC1143766

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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