Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sequence Variation in a Newly Identified HLA-B35-Restricted Epitope in the Influenza A Virus Nucleoprotein Associated with Escape from Cytotoxic T Lymphocytes

1 Mar 2002

Abstract excerpt

Here, we describe a new HLA-B*3501-restricted cytotoxic T lymphocyte (CTL) epitope in the influenza A virus (H3N2) nucleoprotein, which was found to exhibit a high degree of variation at nonanchor residues. The influenza virus variants emerged in chronological order, and CTLs directed against old variants failed to recognize more recent strains of influenza A virus, indicating an escape from CTL immunity.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Cell Function and Interaction
Share to Immunotherapy and Immune Responses
Share to Influenza Virus Research Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11836437
DOI: 10.1128/jvi.76.5.2567-2572.2002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sequence Variation in a Newly Identified HLA-B35-Restricted Epitope in the Influenza A Virus Nucleoprotein Associated with Escape from Cytotoxic T LymphocytesPMID 11836437Read ↗

Sequence variation in the influenza A virus nucleoprotein associated with escape from cytotoxic T lymphocytes.Semantic proximity Read ↗

Assessment of the extent of variation in influenza A virus cytotoxic T-lymphocyte epitopes by using virus-specific CD8+ T-cell clonesSemantic proximity Read ↗

Long-term adaptation of the influenza A virus by escaping cytotoxic T-cell recognitionSemantic proximity Read ↗

Antigenic drift in the influenza A virus (H3N2) nucleoprotein and escape from recognition by cytotoxic T lymphocytes.Semantic proximity Read ↗

Influenza virus CTL epitopes, remarkably conserved and remarkably variable.Semantic proximity Read ↗

Nucleoprotein of influenza A virus is a major target of immunodominant CD8+ T-cell responses.Semantic proximity Read ↗

Emergence of new influenza A viruses which carry an escape mutation of the HLA-B27-restricted CTL epitope of NP in Japan.Semantic proximity Read ↗

Highly conserved influenza A sequences as T cell epitopes-based vaccine targets to address the viral variability.Semantic proximity Read ↗

[The impact of conservative and hypervariable immunodominant epitopes in internal proteins of the influenza A virus on cytotoxic T-cell immune responses].Semantic proximity Read ↗

Systematic identification of immunodominant CD8 <sup>+</sup> T-cell responses to influenza A virus in HLA-A2 individualsSemantic proximity Read ↗

Identification and structural definition of H5-specific CTL epitopes restricted by HLA-A*0201 derived from the H5N1 subtype of influenza A virusesSemantic proximity Read ↗

Viral Escape by Selection of Cytotoxic T Cell–Resistant Variants in Influenza a Virus PneumoniaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.