Article
Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8+ T cells in influenza virus-infected mice.
Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2003
Johnson Barbara J, Costelloe Elaine O, Fitzpatrick David R, Haanen John B A G, Schumacher Ton N M, Brown Lorena E, Kelso Anne
Abstract excerpt
Influenza virus infection activates cytolytic T lymphocytes (CTL) that contribute to viral clearance by releasing perforin and granzymes from cytoplasmic granules. Virus-specific, perforin-dependent CD8(+) CTL were detected in freshly isolated cells from the mouse lung parenchyma but not from the mediastinal lymph nodes (MLN), where they are primed, or from the spleen during primary influenza virus infection. To...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.