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Stem cell protein Piwil2 modulates expression of murine spermatogonial stem cell expressed genes

31 Oct 2005

Abstract excerpt

The piwi family genes are highly conserved during evolution and play essential roles in stem cell self-renewal, gametogenesis, and RNA interference in diverse organisms ranging from Arabidopsis to human. Piwil2, known also as Mili gene, is one of three mouse homologues of piwi. Piwil2 was found in germ cells of adult testis, suggesting that this gene functions in spermatogonial stem cell self-renewal. In order to...

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PMID: 16261612
DOI: 10.1002/mrd.20391

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