Synergistic interaction of heterozygous deletions impairs performance and confers susceptibility to disease at all ages.

Abstract excerpt

Rare recessive conditions are more common in the offspring of cousin unions than in the general population even in communities in which less than 0.5% of all marriages are between first cousins. It is shown that if the human genome has 30,000 genes in the haploid set then (Y+X)6/(Y)5 < 19, where X is the mean number of new mutations entering the human genome per generation and Y is the mean number of heterozygous...

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