Article
Alternative splicing and promoter use in the human GABRA2 gene.
Brain research. Molecular brain research - 13 Jun 2005
Tian Huijun, Chen Hui-Ju, Cross Tiffeny H, Edenberg Howard J
Abstract excerpt
GABA(A) receptors mediate the majority of the fast synaptic inhibition in the mammalian brain. They are the targets of several important drugs, including benzodiazepines, which are used as anxiolytics, sedatives, anti-convulsants, and in the treatment of alcohol withdrawal symptoms. Non-coding variations in GABRA2, the gene encoding the alpha2 subunit, are associated with the risk for alcoholism, suggesting that...
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