Article
Structural comparison of major histocompatibility complex class I molecules and homology modelling of five distinct human leukocyte antigen-A alleles.
Protein engineering - 1 Dec 1996
Chelvanayagam G, Jakobsen I B, Gao X, Easteal S
Abstract excerpt
The peptide complexes of 19 major histocompatibility complex class I alpha 1 and alpha 2 domains have been compared to identify similarities that can be interpreted as constraints necessary for the function or stability of the molecule. It was found that nearly half of the residues maintained the...
Topics
- Alleles
- Amino Acid Sequence
- Binding Sites
- Computer Simulation
- Evolution, Molecular
- Forecasting
- HLA-A Antigens
- Histocompatibility Antigens Class I
- Humans
- Models, Molecular
- Molecular Sequence Data
- Peptides
- Protein Binding
- Receptors, Antigen, T-Cell
- Sequence Homology, Amino Acid